Infertility is a condition of the reproductive system that prevents the conception of children. Infertility, as defined by The International Committee for Monitoring Assisted Reproductive Technologies (ICMART), is a disease characterized by the failure to establish a clinical pregnancy after 12 months of regular, unprotected sexual intercourse or due to an impairment of a person’s capacity to reproduce either as an individual or with his/her partner.
It affects approximately 10-15% of couples throughout the United States. The diagnosis of infertility is usually given to couples who have been attempting to conceive for at least 1 year without success.
Identifies chromosomal abnormalities and DNA mutations that correlate with infertility related disorders. Typically genetic abnormalities are the cause of spontaneous abortions and increases the possibility that a baby will be born with a specific medical condition
During the diagnostic work-up of both male and female infertility, various blood tests have to be conducted prior to assisted reproduction attempts in order to verify the presence or absence of various infectious diseases, which could be a contributing factor to a couple’s infertility issues.
A term used to determine the capacity of the ovary to provide eggs. Essentially egg quantity is what is being measured and gives an estimation of the number of eggs a woman has remaining for future use.
2-3 consecutive miscarriages in the first or early second trimester. Many factors can be involved including: genetic/chromosomal, age, hormones, metabolic abnormalities, anatomic abnormalities, immunological problems, clotting disorders and more.
Refers to inherited or acquired disorders that can result in an increased chance for abnormal blood clotting. During pregnancy this can cause microscopic clots to form in the placenta depriving the fetus of adequate blood flow.
Zika virus infection is primarily spread to people through mosquito bites. It can also be passed by infected individuals to their partner during sex. A pregnant woman infected with Zika virus can pass the virus to her developing fetus and many who are infected do not have any symptoms.
Any condition that interferes with a male’s ability to initiate a pregnancy with the female partner. There are a wide range of causes that can be tested for and are due to genetics, hormonal disorders, sperm function or sperm quantitative/qualitative features.
The MRH panel identifies approximately 35% of the males whose sperm are analyzed in the tests as having male related issues. It is made up of three tests: Sperm DNA Accelerated Decondensation (SDAD) Test, Sperm DNA Decondensation (SDD) Test, and Sperm Chromatin Fragmentation Assay (SCFA)
Once a sperm has fertilized an egg, the DNA message must go through a transformational process in order for it to combine with the eggs DNA. The first step in this process is decondensation. SDD Test assess whether or not sperm DNA goes through normal decondensation process. Failure to go through the normal process may result in an unreadable DNA message which could cause miscarriages, or no pregnancy at all.
The SCFA is a DNA integrity test that assesses the physical structure of sperm DNA identifying patients with a high DNA Fragmentation Index (DFI) test score. Such patients have compromised DNA integrity. If there is too much damage (also known as DNA breaks) to key parts of the DNA message, then the DNA may be rendered either partially or completely unreadable and the pregnancy may terminate prematurely, or not occur at all.
For further information regarding the SCFA call Unilab at 877-522-5678